韩安家主任医师

科室：内科

擅长：软组织肿瘤和呼吸系统疾病的病理诊断

简介：韩安家，男，主任医师，中山大学附属第一医院病理科/中山医学院病理学教研室副主任，教授，硕士生导师。擅长软组织肿瘤和呼吸系统疾病的病理诊断，主要从事结直肠癌和软组织肿瘤发病机制研究。现任中华医学会病理学分会第十届委员会青年委员会副主任委员，广东省临床病理质量控制中心副主任兼秘书，广东省医学会病理学分会常委兼秘书，广东省医学会病理学分会软组织和骨肿瘤病理协作组组长。中华医学会病理学分会软组织和骨肿瘤病理学组（筹）委员。国家自然科学基金、中国博士后科学基金、广东省自然科学基金、北京市自然科学基金等项目评审专家。2004-2007年在University of Pittsburgh, Montefiore Medical Center, University of Illinois at Chicago作访问学者。2012年在University of Texas Southwestern Medical Center进行临床观摩学习。

主持国家自然科学基金、广东省自然科学基金等多项。近5年来在J PATHOL，JNCI，EUR J CANCER，INT J CANCER，CARCINOGENESIS，MOL CARCINOGEN，PLOS ONE等发表论著40余篇。

主编《软组织肿瘤病理学诊断图谱》（科学出版社，2014）、 《病理学教学彩色图谱》（科学出版社，2003年）；参编《病理学高级教程》、《病理学》（研究生用）、《病理学与病理生理学》、《病理学与病理生理学学习指南》、《外科病理学》、《疑难外科病理诊断与鉴别诊断》、《现代肺癌病理与临床》等多部。

担任INT J CANCER, J MED VIROL, J Tumor，《中华病理学》，《临床与实验病理学杂志》，《中华肿瘤防治杂志》等编委和特邀审稿专家。获《中华病理学杂志》50周年金笔奖。

代表作 (通讯作者):
1.Zhen T, Dai S, Li H, Yang Y, Kang L, Shi H, Zhang F, Liang Y, Han A*. MACC1 promotes carcinogenesis of colorectal cancer via β-catenin signaling. Oncotarget. 2014 (advance online publications) （IF 6.636）
2.Li H, Dai S, Zhen T, Shi H, Zhang F,Yang Y, Kang L, Liang Y, Han A*. Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. Eur J cancer 2014, 50(6):1207-1221 (IF 5.06)
3.Cao Q, Liu F, Niu G, Xue L, Han A*. Blastic plasmacytoid dendritic cell neoplasm with EWSR1 gene rearrangement.J Clin Pathol. 2014 Jan;67(1):90-2. (IF 2.44)
4.Yang Y, Li H, Zhang F, Shi H, Zhen T, Dai S, Kang L, Liang Y, Wang J, Han A*. Clinical and biological significance of hepatoma-derived growth factor in Ewing's sarcoma. J Pathol. 2013 Nov;231(3):323-34. (IF 7.59)
5.Hu K, Liao D, Wu W, Han AJ, Shi HJ, Wang F, Wang X, Zhong L, Duan T, Wu Y, Cao J, Tang J, Sang Y, Wang L, Lv X, Xu S, Zhang RH, Deng WG, Li SP, Zeng YX, Kang T*.. Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma.Oncotarget 2013 Mar 21. [Epub ahead of print] （IF 6.636）
6.Zhang F, Yang Q, Meng F, Shi H, Li H, Liang Y, Han A*. Astrocyte elevated gene-1 interacts with β-catenin and increases migration and invasion of colorectal carcinoma. Mol Carcinog. 2013 Aug;52(8):603-10 (IF 4.27)
7.Meng F, Li H, Shi H, Yang Q, Zhang F, Yang Y, Kang L, Zhen T, Dai S, Dong Y, Han A*. MACC1 down-regulation inhibits proliferation and tumourigenicity of nasopharyngeal carcinoma cells through Akt/β-catenin signaling pathway. PLoS One. 2013;8(4):e60821. (IF 3.73)
8.Yang Y, Zhen T, Zhang F, Dai S, Kang L, Liang Y, Xue L, Han A*. p53 and hepatoma-derived growth factor expression and their clinicopathological association with Ewing family tumour.J Clin Pathol. 2014 Mar;67(3):235-42 (IF 2.44)
9.Chen W, Shi H, Liu Y, Ke Z, Han A*. Endotracheal angiomatoid 'malignant' fibrous histiocytoma: EWSR1 gene rearrangement.Pathology. 2013 Aug;45(5):506-8 (IF 2.66)
10.Ye Z, Cao Q, Niu G, Liang Y, Liu Y, Jiang L, Yu X, Han A*. p63 and p53 expression in extranodal NK/T cell lymphoma, nasal type. J Clin Pathol. 2013 Aug;66(8):676-80. (IF 2.44)
11.Tang QL, Xie XB, Wang J, Chen Q, Han AJ, Zou CY, Yin JQ, Liu DW, Liang Y, Zhao ZQ, Yong BC, Zhang RH, Feng QS, Deng WG, Zhu XF, Zhou BP, Zeng YX, Shen JN, Kang T. Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma . J NATL CANCER I, 2012 May 16;104(10):749-63. (IF 14.34)
12.Liu D, Shi H, Ke Z, Han A*. Primary cardiac diffuse large B-cell lymphoma, non-germinal centre B-cell type in an immunocompetent woman. Interact Cardiovasc Thorac Surg. 2012 Aug;15(2):282-4.
13.Xiao P, Shi H, Zhang H, Meng F, Peng J, Ke Z, Wang K, Liu Y, Han A*. Epstein-Barr virus-associated intrahepatic cholangiocarcinoma bearing an intense lymphoplasmacytic infiltration. J Clin Pathol. 2012 Jun;65(6):570-3. (IF 2.44)
14.Song Y, Yang QX, Zhang F, Meng F, Li H, Dong Y, Han A*. Suppression of nasopharyngeal carcinoma cell by targeting β-catenin signaling pathway. Cancer Epidemiol. 2012; 36(2):e116-21 (IF 2.23)
15.Cai XD, Zhou YB, Huang LX, Zeng QL, Zhang LJ, Wang QQ, Li SL, Feng JQ, Han AJ. Reduced expression of Krüppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma. Biochem Biophys Res Commun. 2012 Feb 3;418(1):67-73. (IF 2.41)
16.Sun S, Ke Z, Wang F, Li S, Chen W, Han A, Wang Z, Shi H, Wang LT, Chen X. Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Hum Pathol. 2012 Jul;43(7):1051-60. (IF 2.84)
17.Wang Z, Yang S, Shi H, Du H, Xue L, Wang L, Dong Y, Han A*. Histopathological and immunophenotypic features of testicular tumour of the adrenogenital syndrome. Histopathology 2011;58(7):1013-8 (IF 2.86)
18.Ye Z, Xiao Y, Shi H, Ke Z, Liu Y, Liang Y, Han A*. Sporadic Burkitt lymphoma in southern China: 12 years' experience in a single institution in Guangzhou. J Clin Pathol. 2011 Dec;64(12):1132-5. (IF 2.44)
19.Zhang F, Meng F, Li H, Dong Y, Yang W, Han A*. Suppression of retinoid X receptor alpha and aberrant β-catenin expression significantly associates with progression of colorectal carcinoma. Eur J Cancer. 2011 Sep;47(13):2060-7. (IF 5.06)
20.Ye C, Pan L, Huang Y, Ye R, Han A, Li S, Li X, Wang S. Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations. J Vasc Surg. 2011 Dec;54(6):1760-1768. (IF 2.88)
21.Ye C, Yin H, Lin Y, Zhou L, Ye R, Li X, Han A, Wang S. Abdominal Aorta Aneurysms in Children: Single-Center Experience of Six Patients. Ann Thorac Surg. 2011 Jan;93(1):201-5 (IF 3.45)
22.You S, Zhang F, Meng F, Li H, Liu Q, Liang Y, Dong Y, Yang W, Han A*. EBV-encoded LMP1 increases nuclear β-catenin accumulation and its transcriptional activity in nasopharyngeal carcinoma. Tumour Biol. 2011 Aug;32(4):623-30.PMID: 21336584(IF 2.52)
23.Ye Z,Shi H, Peng T, Han A*.Clinical and pathological features of high grade primary cardiac osteosarcoma. Interact Cardiovasc Thorac Surg. 2011 Jan;12(1):94-5 PMID: 21098423
24.Xiao P, Liu D, Peng J, Gao Z, Dong Y, Wu H, Han A*. Aggressive angiomyxoma of sphenoidal sinus. Pathology 2011；43(1):79-81 PMID: 21240074 (IF 2.66)
25.Liu D,Xiao P, Gao Z, Xue L, Wang L, Liu Y, Han A*.Chondroblastoma with adamantinoma differentiation of the calcaneus. Pathology 2011;43(2)：174-176 PMID: 21233685 (IF 2.66)
26.Yang J, Zhang F, Fang H, Ye Z, Lin S, Han A*. Clinicopathologic features of primary lymphoma in soft tissue. Leuk Lymphoma. 2010 Nov;51(11):2039-46 PMID: 20929318 (IF 2.30)
27.Fang HQ, Yang J, Zhang FF, Cui Y, Han AJ*. Clinical and Pathological features of Gastric glomus tumors. World J Gastroenterology, 2010；16(36): 4616-4620 PMID: 20857536 (IF 2.55)
28.Liu Q, Han A*, You S, Yang Q, Liang Y, Dong Y. The association of genomic variation of Epstein–Barr virus BamHI F fragment with the proliferation of nasopharyngeal carcinoma. APMIS 2010; 118(9):657-64. PMID: 20718717 (IF 2.07)
29.Liu L, Wu J, Ying Z, Chen B, Han A, Liang Y, Song L, Yuan J, Li J, Li M. Astrocyte elevated gene-1 upregulates matrix metalloproteinase- 9 and induces human glioma invasion. Cancer Res. 2010; 70(9):3750-9 PMID: 20388776 (IF 8.65)
30.Fang W, Han A, Bi X, Xiong B, Yang W. Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling. Int J Cancer. 2010; 127(1): 32-42 PMID: 19904745 (IF 6.20)
31.Hu D, Bi X, Fang W, Han A, Yang W. GSK3β is involved in JNK2-mediated β-catenin inhibition. PLoS One. 2009 Aug 13;4(8):e6640 PMID: 19675674 (IF 3.73)
32.Wang Z, Yang Shicong, Wang LT, Han A*. Primary extrauterine undifferentiated endometrial sarcoma with osseous and cartilaginous differentiation. Pathology, 2009; 41(5):503-505 PMID: 19900096 (IF 2.66)
33.Han A., Tong C., Hu D.,Bi X., Yang W. A direct protein-protein interaction is involved in the suppression of β-catenin transcription by retinoid X receptor α in colorectal cancer cells. Cancer Biol Ther. 2008; 7(3) 454-459 PMID: 181196974
34.Han A.，Song Z, Tong C, Hu D, Bi X, Augenlicht LH, Yang W.Sulindac suppresses β-catenin expression in human cancer cells. Eur J Pharmacol. 2008; 583(1) 26-31 PMID: 18291362
35.Hu D, Fang W, Han A, Gallagher L, Davis RJ, Xiong B, Yang W. c-Jun NH2-terminal kinase 1 interacts with and negatively regulates Wnt/{beta}-catenin signaling through GSK3{beta} pathway. Carcinogenesis. 2008；29(12):2317-24 PMID: 18952597
36.Feng C, Han A, Ye C, Xu R, Li M. The HMG-CoA Reductase Pathway, Statins and Angioprevention. Semin Ophthalmol. 2006, 21(1):29-35 PMID: 16517442
37.Han AJ*, Xiong M, Gu YY, et al. Lymphoepithelioma-like carcinoma of the lung with a better prognosis: A clinicopathologic study of 32 cases. Am J Clin Pathol 2001,115(6): 841-850 PMID: 11392880
38.Han AJ*, Xiong M, Zong YS. Association of Epstein-Barr Virus with lymphoepithelioma-like carcinoma of the lung in Southern China. Am J Clin Pathol 2000,114(2):220-226 PMID: 10941337