陈继红主任医师
科室:内科
擅长:胃食管反流病、便秘、肠易激综合症等消化动力障碍性疾病和功能性胃肠疾病、消化性溃疡、消化道癌前疾病、慢性肝病等的基础与临床研究和相关...
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简介:陈继红,湖北襄阳人,武汉大学人民医院消化内科教授/主任医师/博士生导师/ 留美学者。现为加拿大McMaster大学消化内科Clinical Fellow,专研胃肠动力疾病的临床诊治。功能性胃肠疾病国际机构罗马基金会(Rome Foundation)会员;亚洲神经胃肠病学和动力学会(ANMA’s Scientific Committee)2012教学项目教师;UpToDate翻译专家;中华医学会内科学会青年委员会委员;湖北省武汉市消化学会常委;湖北省抗癌协会肝癌专业委员会常委;中国胃肠动力基础与临床研究和培训基地负责人。武汉大学与芝加哥大学教学改革合作项目(WUMER project)课程教师。《Frontiers in Autonomic Neuroscience》编辑审稿人,《PLoS One》 《Nuerogastroenterology and Motility》《European Journal of Physiology》《British Journal of Medicine and Medical Research》《World Journal of Gastroenterology》《肿瘤防治研究》审稿人。主要研究方向:胃肠运动相关性疾病的神经胃肠病学机制研究。主持国家自然科学基金和国家级医学教育研究立项课题2项,参加美国NIH研究项目三项、主持省级课题四项和武汉大学教学课题四项。开设武汉大学通识课程1门《饮食情绪与胃肠运动》;参编《实用消化病学》、卫生部诊断学教材等专著5部,主译《德高文物理诊断学》,发表SCI论文15篇,国内论文20余篇。
Jihong Chen, MD,PhD. Professor of medicine.Director of GI motility lab,Department of Gastroenterology and Hepatology,Renmin Hospital of Wuhan University.
Clinical Fellow, Department of Gastroenterology, Farncombe Family
Digestive Health Research Institute, McMaster University.
Rome Foundation (Rome Foundation) membership.Member of ANMA’s Scientific Committee; Standing member of Wuhan Digestive Diseases Association;
Editor reviewer of《Frontiers in Autonomic Neuroscience》,reviewer of《PLoS One》《European Journal of Physiology》,《British Journal of Medicine and Medical Research》and《Prevention and Treatment of Cancer》. Course director of 《Clinical Reasoning》in WUMER project (Wuhan University Medical Reform Project with University of Chicago).Research interest: neurogastroenterology.
研究课题(Grants)
Principal Investigator:
National Natural Science Foundation of China, 81170349, Relationship between Interstitial cells of Cajal and colonic motolity in chronic constipation, 2012-2016, 500,000RMB;
Research Foundation from Health Department of Hubei Province, JX5B11, Mechanisms of liver metastasis in various degrees of differentiation , 2011.12-2012.12, 30,000RMB;
Project of Science and Technology Department of Hubei Province, The role of intestinal neurogenic inflammation in acute stress, 2010.1-2013.12, 30,000RMB;
Ipsen the diarrhea Fund (IDF) , 2010HX0026, Smecta protection mechanisms of intestinal neurogenic inflammation in the acute stress, 2010.5—2012.5, 98,000RMB;
Wuhan University Foundation, EJY020032, Task-based Teaching(TBL) in the Course of Physical Examination, 2002-2005, 5000RMB;
Norvatis Research Foundation, Effects of Tegasero on acute injury of GI tract in rats,2005-2007, 30000RMB;
Guangdong Meize Pharmaceuticals Company Research Foundation, Effects of Jinsuangqi on the colon-rectal motility of patients with IBS, 2003-2005, 24400RMB;
Research Foundation from Health Department of Hubei Province, JX2C56, Effects of mast cell mobilizer on stressful injury of GI tract in rats, 2005-2006, 10000RMB;
发表的论文(Selected publications)
The origin of segmentation motor activity in the intestine.
Huizinga JD, Chen JH, Fang Zhu Y, Pawelka A, McGinn RJ, Bardakjian BL, Parsons SP, Kunze WA, Wu RY, Bercik P, Khoshdel A, Chen S, Yin S, Zhang Q, Yu Y, Gao Q, Li K, Hu X, Zarate N, Collins P, Pistilli M, Ma J, Zhang R, Chen D.
Nat Commun. 2014 Feb 24;5:3326.
Interstitial cells of Cajal: update on basic and clinical science. Huizinga JD, Chen JH. Curr Gastroenterol Rep. 2014 Jan;16(1):363.
Chen JH, Wang XY, Liu LW, Yu W, Yu Y, Zhao L, Huizinga JD. On the origin of rhythmic contractile activity of the esophagus in early achalasia, a clinical case study. Front Neurosci. 2013 May 21;7:77.
Li KL, Chen JH, Zhang Q, Huizinga JD, Vadakepeedika S, Zhao YR, Yu WZ, Luo HS. Habitual rapid food intake and ineffective esophageal motility. World J Gastroenterol. 2013;19(14):2270-7.
Chen JH, Zhang Q, Yu Y, Li K, Liao H, Jiang L, Hong L, Du X, Hu X, Chen S, Yin S, Gao Q, Yin X, Luo H, Huizinga JD. Neurogenic and myogenic properties of pan-colonic motor patterns and their spatiotemporal organization in rats. PLoS One. 2013;8(4):e60474.
Huizinga JD, Chen JH, Mikkelsen HB, Wang XY, Parsons SP, Zhu YF. Interstitial cells of Cajal, from structure to function. Front Neurosci. 2013 Apr 1;7:43.
Theoharides TC, Asadi S, Chen JH, Huizinga JD Editorial: Irritable Bowel Syndrome and the Elusive Mast Cells. Am J Gastroenterol 2012,107, 727-729.
Jihong Chen, Hanaa S Sallam, Lin Lin, Jiande Chen. Colorectal and Rectocolic Reflexes in Canines: Involvement of Tone, Compliance and Anal Sphincter Relaxation. Am J Physiol Regul Integr Comp Physiol. 2010 Jun 16.
Chen JH, Song GQ, Yin J, Sun Y, Chen JD Gastric electrical stimulation reduces visceral sensitivity to gastric distention in healthy canines. Auton Neurosci 160, 16-20.
Chen J, Xing J, Chen JD (2009) Effects of muscarinic receptor stimulation and nitric oxide synthase inhibition on gastric tone and gastric myoelectrical activity in canines. J Gastroenterol Hepatol 24, 1130-1135.
Chen JH, Wei SZ, Chen J, Wang Q, Liu HL, Gao XH, et al. (2009) Sensory denervation reduces visceral hypersensitivity in adult rats exposed to chronic unpredictable stress: evidences of neurogenic inflammation. Dig Dis Sci 54, 1884-1891.
Jihong Chen, Junying Xu Jiande Chen. Evidence of Peripheral Neural Plasticity in Diet-Induced Obese (DIO) Rats: Expression of Immunoreactive NPY in Lumbar DRGs and Dorsal Horn of Spinal Cord. Gastroenterology. 2007, Vol132, Suppl 2, A248-249
Min C, Hesheng L, Jihong C, Qiaoyun T, Xianzhen L, Chireyeth S (2005) Effects and mechanism of changes of local neurotransmitters in rats' pylorus and bile reflux to the stomach with stress ulcer. Dig Dis Sci 50, 1898-1903.
Zhongyin Z, Hesheng L, Jun L, Jihong C (2006) Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas. Saudi Med J 27, 161-164.
Zhao X, Yin J, Chen J, Song G, Wang L, Zhu H, et al. (2009) Inhibitory effects and mechanisms of intestinal electrical stimulation on gastric tone, antral contractions, pyloric tone, and gastric emptying in dogs. Am J Physiol Regul Integr Comp Physiol 296, R36-42.
陈继红等, 案例教学法在临床医学教学中的组织与实施. 中国高等医学教育, 2011(4): 第95-96,118页.
王翠云等, 结肠宁保留灌肠治疗溃疡性结肠炎的疗效评价. 现代中西医结合杂志, 2011. 20(16): 第1962-1963页.
龚豪等, 幽门螺杆菌感染与小儿再发性腹痛的Meta分析. 武汉大学学报(医学版), 2011. 32(4): 第497-501页.
陈继红等, 案例教学法与以问题为基础学习教学法相结合在内科学消化系统教学中的应用. 中华医学教育杂志, 2010. 30(2): 第250-252页.
高凌, 叶惠凤与陈继红, 体表胃肠起搏治疗糖尿病胃病临床研究. 河北医药, 2010. 32(20): 第2842-2843页.
陈振华等, 盐酸氟西汀对抑郁模型大鼠胃窦肥大细胞胰蛋白酶-1的影响. 武汉大学学报(医学版), 2010. 31(5): 第596-599页.
魏少忠等, 肿瘤坏死因子相关凋亡诱导配体对Omi/HtrA2不同表达水平前列腺癌细胞的促凋亡作用. 中华实验外科杂志, 2010. 27(4): 第507-509页.
陈振华等, 补肾壮阳胶囊对抑郁模型大鼠行为学的影响. 武汉大学学报(医学版), 2009. 30(6): 第752-755页.
陈继红等。辣椒素敏感的感觉神经参与大鼠慢性应激所致的内脏高敏感. 中华消化杂志, 2009. 29(11): 第746-750页.
陈振华等, 抑郁模型大鼠胃窦部变态反应及超微结构改变. 中国病理生理杂志, 2009. 25(1): 第148-151页.
陈继红等, 表皮生长因子受体和血管内皮生长因子在胃肠间质瘤中的表达及其意义. 中华实验外科杂志, 2008. 25(11): 第1435-1437页.
王清等, 地氯雷他定对慢性应激大鼠肠道肥大细胞的影响. 武汉大学学报(医学版), 2008. 29(2): 第218-221,226页.
陈继红等, 人胃癌组织中Smac和Livin的表达及其临床意义. 中华实验外科杂志, 2008. 25(7): 第886-887页.
魏少忠, 陈继红与陈健, Smac和Ki67在胃癌组织中的表达及其临床意义. 肿瘤防治研究, 2007. 34(12): 第937-939页.
陈敏等, 应激性溃疡时胃内胆汁酸的变化及铝碳酸镁的保护作用. 中华消化杂志, 2005. 25(4): 第248-250页.
陈敏等, 大鼠应激性溃疡幽门区降钙素基因相关肽及一氧化氮变化对胃内胆汁反流的影响. 世界华人消化杂志, 2004. 12(9): 第2131-2134页.
魏少忠,陈继红, 胃肠道间质瘤的诊治. 肿瘤防治研究, 2004. 31(10): 第659-661页..
陈继红等, 2.18Valsalva试验对食管胃屏障压的影响. 基础医学与临床, 2003. 23(z1): 第51-52页.
陈继红,罗和生, 非门脉高压性呕血病因分析. 中华消化杂志, 2003. 23(3): 第185-185页.
魏少忠, 张克亮与陈继红, 重组人表皮细胞生长因子促进Mile's术后会阴部伤口愈合的临床观察. 肿瘤防治研究, 2002. 29(3): 第224-225页.
陈继红等, 顽固性功能性消化不良患者临床特征分析. 胃肠病学和肝病学杂志, 2001. 10(2): 第145-146页.
陈继红等, 影响功能性消化不良症状严重程度的心理学因素. 中华消化杂志, 2001. 21(7): 第436-437页.
魏少忠等, p16基因在膀胱肿瘤细胞凋亡中的作用. 肿瘤防治研究, 2000. 27(2): 第97-98页.
魏少忠, 陈继红与陈健, Smac和Ki67在胃癌组织中的表达及其临床意义. 肿瘤防治研究.
陈继红等, 案例教学法在临床医学教学中的组织与实施. 中国高等医学教育,.
陈振华等, 补肾壮阳胶囊对抑郁模型大鼠行为学的影响. 武汉大学学报(医学版).
高凌, 叶惠凤与陈继红, 体表胃肠起搏治疗糖尿病胃病临床研究. 河北医药.
陈继红等, 顽固性功能性消化不良患者临床特征分析. 胃肠病学和肝病学杂志.
魏少忠与陈继红, 胃肠道间质瘤的诊治. 肿瘤防治研究.
魏少忠, 张克亮与陈继红, 重组人表皮细胞生长因子促进Mile’s术后会阴部伤口愈合的临床观察. 肿瘤防治研究.