简介：王志华，医学博士，副教授，副主任医师。于华中科技大学同济医学院毕业获外科学博士学位（导师叶章群教授），毕业后留附属同济医院泌尿外科从事医疗、科研和教学工作，曾先后于2010年5月参加美国泌尿外科学会AUA住院医师培训项目和2011年3月参加首届中美联合泌尿外科专科医师培训项目，通过系统培训掌握了泌尿系疾病的诊疗理论和操作技术。2012年至2013年以访问学者身份在美国西北大学从事泌尿外科临床和科研工作，师从世界著名泌尿外科专家CATALONA教授（“前列腺PSA之父”），专门研修泌尿系肿瘤的微创手术治疗及晚期肿瘤的综合治疗。
从医十余年，对各种泌尿系结石，泌尿系或腹膜后肿瘤，及男科疾病有较丰富的临床诊治经验，能熟练开展微创技术治疗复杂性肾及输尿管结石（经皮肾镜碎石术和输尿管镜碎石术），尤其擅长肾肿瘤、膀胱癌、前列腺癌、肾盂及输尿管癌和肾上腺肿瘤等泌尿系肿瘤的腹腔镜微创手术治疗。在中南地区率先开展前列腺PSA筛查，早期诊断并治疗前列腺癌。此外，在前列腺癌，肾癌及膀胱癌的个体化治疗和多专科综合治疗等方面也积累了丰富的临床经验。目前主持国家自然科学基金及省部级课题共6项，合作参与其他各类课题10余项，发表专业论文40余篇。参编《泌尿外科关键决策》、《膀胱癌尿流改道手术学》、《前列腺癌诊断治疗学》、《泌尿系肿瘤学》等多部专著。
目前担任学术职务：美国泌尿外科学会（AUA）会员，欧洲泌尿外科学会（EUA）会员，世界腔道泌尿外科学会（WCE）会员，世界泌尿肿瘤联盟（WUOF）会员，美国前列腺癌基金会（PCF）会员，中华医学会泌尿外科学分会湖北省青年委员，《现代泌尿生殖肿瘤杂志》主编助理及编委，《汉斯外科学》杂志编委。并担任《Molecular Biology Reports》、《Oncology Letter》、《国际临床报告》、《中华实验外科杂志》、《中华外科杂志》、《肿瘤防治研究》、《临床泌尿外科杂志》等杂志审稿人。
近年发表论文（部分）：
1.Wang Zhihua, Zhou Chun, Ye Qing, et al. Gene Construction and Protein 3D model of anti-PAF ScFv Antibody. Journal of Huazhong University of Science and Technology (Nature Sciences). 2004, 32(6): 114-116.
2.Ye Qing, Wang Zhihua, Wang shuo, et al. Activation Lymphocytes by anti-CD71 mouse/human chimeric antibody in vitro. Chinese Journal of Microbiology and Immunology.2004,24(7)509-513
3.Ye Qing, Wang Zhihua, Zhen Hongyan, et al. Construction and Detection of the Mice Model for Graft Versus Host Disease. Journal of Huazhong University of Science and Technology (Medicine Sciences). 2004，33(6):651-654
4.Yang DF, Zhu HF, Wang ZH, et al. Construction of single chain Fv antibody against transferrin receptor and its protein fusion with alkaline phosphatase. World J Gastroenterol 2005;11(21):3300-3303
5.Wang Zhihua, Ye Qing, Ye Zhangqun, et al.In vitro Anti-tumor Effect of CTL Induced by Hsp70-Id Complex-modified DC. Chinese Journal of Oncology, 2006, 28(6): 481-485.
6.Qing Y, Shuo W, Zhihua W, et al. The in vitro antitumor effect and in vivo tumor-specificity distribution of human-mouse chimeric antibody against transferrin receptor. Cancer Immunol Immunother. 2006,55(9):1111-1121 (SCI, IF:4.319)
7.ZHU LJ, LIAO W, ZHU HF, LEI P, WANG ZH, SHEN GX. Construction, Expression and In Vitro Biological Behaviors of Ig scFv Fragment in Patients with Chronic B Cell Leukemia. Journal of Huazhong University of Science and Technology [Med Sci ].2006, 26 (2):157-160
8.Wang Zhihua, Hu Zhiquan,Ye Zhangqun, et al .Antisense RNA of survivin gene enhance taxol-induced apoptosis in bladder cell line BIU87.Chinese Medicine Journal, 2007, 87(6): 419-424.
9.Shen X, Zhu HF, He FR, Wang ZH, Shen GX.An anti-transferrin receptor antibody enhanced the growth inhibitory effects of chemotherapeutic drugs on human non-hematopoietic tumor cells.Int Immunopharmacol. 2008 Dec 20;8(13-14):1813-20. (SCI, IF:2.157)
10.Liu J, Xiao D, Wang ZH, et al. Preparation and identification of scFv and bsFv against transferrin receptor. J Huazhong Univ Sci Technolog [Med Sci ].2008 Dec;28(6):621-5.
11.YE Qing, WANG Zhi-Hua, QIN Shu-Kui, et al. Preparation of Heat Shock Protein 70 (Hsp70) and Idiotypic Determinant Single-chain Antibody (Id-ScFv) in a Patien with B-cell Chronic Lymphatic Leukemia (B-CLL) and Antitumor Effect of Peptide Complex Hsp70-Id. Chinese Oncology Research. 2008; 27(2):133-8.
12.Chen XG, Liu F, Song XF, Wang ZH, Zhuang QY,et al. Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways [J]. Mol Carcinog. 2010 Jun; 49(6):603-10.(IF3.6)
13.Qing Ye, Zhihua Wang, Yanshu Li, et al.The effect of anti-TfR mouse/human chimeric antibody on Anti-Transplant rejection. Transpl Int. 2011 Feb;24(2):167-74..（共同第一作者) (IF3.2)
14.LIU Shuanglin,WANG Zhihua, HU Zhiquan, et al.Curcumin exerts anti-tumor activity in androgen independent prostate cancer cells via inhibition of NF-κB and AP-1 pathway in vitro. J Huazhong Univ Sci Technolog [Med Sci ].2011 ,31(4):530-534
15.WANG Zhi-hua, LI You-yuan, HU Zhi-quan, ZHU Hui, ZHUANG Qian-yuan, QI Yong , YE Zhang-qun. Does urothelial cancer of bladder behave differently in young patients? Chinese Medical Journal, Chin Med J (Engl). 2012 Aug; 125(15):2643-8.
16.Wang Z, Lu T, Du L, Hu Z, Zhuang Q, Li Y, Wang CY, Zhu H, Ye Z. Plasmacytoid urothelial carcinoma of the urinary bladder: a clinical pathological study and literature review. Int J Clin Exp Pathol. 2012;5(6):601-8.
17.Zhang S, Lv JW, Yang P, Yu Q, Pang J, Wang Z, Guo H, Liu S, Hu J, Li J, Leng J, Huang Y, Ye Z, Wang CY. Loss of dicer exacerbates cyclophosphamide-induced bladder overactivity by enhancing purinergic signaling. Am J Pathol. 2012 Sep;181(3):937-46.
18.Wang Q, Shu R, He H, Wang L, Ma Y, Zhu H, Wang Z, Wang S, Shen G. Co-silencing of Birc5 (survivin) and Hspa5 (Grp78) induces apoptosis in hepatoma cells more efficiently than single gene interference. Int J Oncol. 2012 Aug;41(2):652-60.
19.Li Y, Zhuang Q, Hu Z, Wang Z, Zhu H, Ye Z. A modified ureteroileal anastomosis technique for Bricker urinary diversion. Urology. 2011 Nov;78(5):1191-5.
20.Qing Ye, Heyu Hu, Zhihua Wang, Tong Lu, Zhiquan Hu, Xing Zeng, Shu Zhang, Jing Liu, Ping Lei, Cong-Yi Wang, Zhangqun Ye and Guanxin ShenGeneration and functional characterization of the anti-transferrin receptor single-chain antibody-GAL4 (TfRscFv-GAL4) fusion protein. BMC Biotechnology. 2012, 12:91. (通讯作者)
21.Zeng X, Hu Z, Wang Z, Tao J, Lu T, Yang C, Lee B, Ye Z.Upregulation of RASGRP3 expression in prostate cancer correlates with aggressive capabilities and predicts biochemical recurrence after radical prostatectomy. Prostate Cancer Prostatic Dis. 2014 Jan 14. doi: 10.1038/pcan.2013.51. [Epub ahead of print] (通讯作者)
22.Tong Lu, Zhihua Wang, et al. Knockdown of GRP78/Bip expression by asymmetric siRNA induces prostate cancer cells undergoing apoptosis along with attenuated capability for migration. Molecular Medicine Reports. 2014 (accepted) (通讯作者)
23.王志华，陈忠。雄激素替代疗法是否增加前列腺癌的风险。现代肿瘤生殖肿瘤杂志，2010，1（6）：377
24.王志华，李恒，李有元，胡志全，叶章群。前列腺癌干细胞的新技术与新概念。现代肿瘤生殖肿瘤杂志，2010，2（6）：58-59.
25.王志华，刘双林，刘海华，胡志全，李有元，叶章群，陈先国，庄乾元。异位嗜铬细胞瘤的诊断与治疗（附31例报告）。2011，40（1）：1-3
26.王志华，曾星，胡志全，叶章群，王冀，李有元，刘双林，鲁海洋，邓康俐。 bcl-2 反义寡核苷酸增强膀胱癌细胞株BIU87对顺铂的敏感性。中华实验外科杂志. 2011, 28(5): 53-55.
27.王志华，杜立环，胡志全，陈先国，赵 霞，王少刚，庄乾元，叶章群。肾嫌色细胞癌临床病理特征分析。中华外科杂志.2011.48（3）：1-3。
28.王志华，叶庆，胡志全， 叶章群， 余虓， 沈关心。 HSP70-Id复合物修饰的树突状细胞体外诱导特异性抗肿瘤作用。中华肿瘤杂志。2006, 28(6): 481-485.
29.王志华，叶庆， 黄德樱， 胡志全， 叶章群， 阳诺， 刘昊，庄乾元，杨为民，刘继红， 张旭。反义寡核苷酸诱导膀胱癌细胞凋亡及增强其化疗敏感性。中华医学杂志。2007, 87(6): 419-424.
30.王志华，胡志全，叶庆，叶章群， 蔡丹，阳诺，刘昊，庄乾元，杨为民，刘继红，张旭。 膀胱癌患者尿脱落细胞中survivin的检测及其临床应用. 中华实验外科杂志. 2006, 23(8): 959-961.
31.蔡 丹，王志华， 胡志全，张旭，周四维， 叶章群。膀胱癌患者外周血树突状细胞的体外培养扩增和鉴定。中华泌尿外科杂志。2007(7):472-474.
32.胡志全，谌科，王志华，孙璇， 叶章群。胸腺肽α１诱导膀胱癌细胞株BIU87凋亡的实验研究。华中科技大学学报（医学版）。2005, 34 (5):578-579.
33.叶庆，王志华， 镇鸿燕，王硕，朱慧芬，沈关心。人-鼠异基因移植物抗宿主动物模型的建立与检测。 华中科技大学学报(医学版),2004,33(6):651-654.
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